We are a research team focusing on Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). In order to understand the molecular pathogenesis and to identify potential opportunities for therapeutic interventions for ALS and FTLD, we combine high-throughput sequencing with basic biochemistry methods and organotypic slice cultures, as well as human cells. We are particularly interested in mimicking the molecular events triggered by aggregation of ALS/FTLD-linked proteins by inducing the misfolding and aggregation of their native forms, following a prion-like paradigm. We envision building reliable models to study ALS and FTLD, and to identify mechanistic pathways driving their perpetuating progression.
| Contact information | |
|---|---|
| Address | Winterthurerstrasse 190 |
| Phone | +41-44-635-3106 |
| Fax | +41-44-635-6898 |
| magdalini.polymenidou@imls.uzh.ch | |
| Website | Visit the website |
Publications
- Ling SC, Polymenidou M, Cleveland DW (2013) Converging mechanisms in ALS and FTLD through disrupted RNA or protein homeostasis, Neuron, 79, 416-38
- Arnold ES, Ling SC, Huelga SC, Lagier-Tourenne C, Polymenidou M, Ditsworth D, Kordasiewicz HB, McAlonis-Downes M, Platoshyn O, Parone P, Da Cruz S, Clutario K, Swing D, Tessarollo L, Marsala M, Shaw CE, Yeo GW, Cleveland DW (2012) ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor disease without aggregation or loss of nuclear TDP-43, PNAS 110, E736-45
- Lagier-Tourenne C*, Polymenidou M*, Hutt KR*, Vu AQ, Clutario K, Baughn M, Huelga SC, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW and Yeo GW (2012) Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs, Nature Neurosc, 15, 1488-97
- Polymenidou M, Cleveland DW (2012) Prion-like spread of protein aggregates in neurodegeneration Journal of Exp Med, 209, 889-93
- Polymenidou M*, Lagier-Tourenne C*, Hutt KR*, Bennett CF, Yeo GW, Cleveland DW (2012) Misregulated RNA processing in Amyotrophic Lateral Sclerosis Brain Res, Mar 3
Restricted information
| Serving population | |
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| Serving population | Unknown |
| Patient resources | |
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| Population based register | No |
| Clinic based register | No |
| Geographically matched controls | No |
Banks
There are no banks for this centre
| Research activities | |
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| Clinical management research | No |
| Neuro epidemiology | No |
| Neuro physiology | No |
| Neuro imaging | No |
| Neuro psychology | No |
| Neuro pathology | No |
| Genomics | No |
| Transcriptomics | No |
| Metabolomics | No |
Clinical Trials - Industry sponsored
There are no clinical trials for this centre
Clinical Trials - Investigator initiated
There are no clinical trials for this centre