Università degli Studi della Campania Luigi Vanvitelli

    Foundation year2003
    DirectorProf. Gioacchino Tedeschi
    Principal investigatorProf. Francesca Trojsi
    The “ALS Centre – Vanvitelli”, part of the First Division of Neurology, University Hospital “Università degli Studi della Campania Luigi Vanvitelli” in Naples (Italy) (new patients/year: about 80; patients in care/year: about 250), is one of the most endorsed ALS centers in Southern Italy, involved in several major national and international clinical trials on ALS. The research activity of this ALS Centre is also performed at the “MRI Research Centre” of the University of Campania “Luigi Vanvitelli”, a centre of excellence based on a collaborative and multi-investigator neuroimaging research environment (including neurologists, neuropsychologists, bioinformaticians, and bioengineers) focused on medical applications of advanced functional and structural magnetic resonance imaging techniques to study brain. Moreover, this ALS centre is involved in several main clinical/research networks: European Reference Network for rare disease (ERN) –  Neuromuscular Diseases (Euro-NMD); ITALSGEN (ITalian Consortium for ALS GENetics); NiSALS (Neuroimaging Society in ALS) Consortia; and TRICALS.

    Contact Information

    AddressNaplesPiazza Luigi Miraglia 280138 Italy

    ContactUniversità degli Studi della Campania Luigi Vanvitelli

    Restricted information

    Serving population
    Naples: 3.085.000; Campania: 5.802.000 (additionally, Basilicata 562.869; Calabria 1.947.000)

    Patient resources

    Population based register
    Clinic based register
    Geographically matched controles

    Banks

    Research activities

    Clinical management research
    Neuro epidemiology
    Neuro physiology
    Neuro imaging
    Neuro psychology
    Neuro pathology
    Genomics
    Transcriptomics
    Metabolomics

    Publication

    1. Trojsi F, Di Nardo F, D’Alvano G, et al. Resting state fMRI analysis of pseudobulbar affect in Amyotrophic Lateral Sclerosis (ALS): motor dysfunction of emotional expression. Brain Imaging Behav. 2023;17(1):77-89. doi: 10.1007/s11682-022-00744-4
    2. Trojsi F, Siciliano M, Femiano C, et al. Comparative Analysis of  C9orf72 and Sporadic Disease in a Large Multicenter ALS Population: The Effect of Male Sex on Survival of  C9orf72 Positive Patients. Front Neurosci. 2019;13:485. doi: 10.3389/fnins.2019.00485
    3. Trojsi F, Di Nardo F, Santangelo G, et al.
      Resting state fMRI correlates of Theory of Mind impairment in amyotrophic lateral sclerosis.
      Cortex 2017;97:1-16. doi: 10.1016/j.cortex.2017.09.016
    4. Santangelo G, Siciliano M, Trojano L, Femiano C, Monsurrò MR, Tedeschi G, Trojsi F. Apathy in amyotrophic lateral sclerosis: insights from Dimensional Apathy Scale. Amyotroph Lateral Scler Frontotemporal Degener 2017;18(5-6):434-442. doi: 10.1080/21678421.2017.1313865
    5. Trojsi F, Esposito F, de Stefano M, Buonanno D, Conforti FL, Corbo D, Piccirillo G, Cirillo M, Monsurrò MR, Montella P, Tedeschi G. Functional overlap and divergence between ALS and bvFTD. Neurobiol Aging. 2015;36(1):413-23. doi:10.1016/j.neurobiolaging.2014.06.025
    For other publications, see: https://www.scopus.com/authid/detail.uri?authorId=14521622200