The San Raffaele ALS Centre is designed and dedicated to providing the highest level of comprehensive care for people and families with ALS and related motor neuron diseases. The infrastructure of this unit comprises: the San Raffaele Neurology Ward, Neurorehabilitation Ward and outpatient ALS clinics. A multi-disciplinary team of experts is committed to providing the highest level of diagnostic accuracy (including the latest neurophysiological tests, MRI, nerve and muscle pathology techniques), and comprehensive, multi-disciplinary patient care and management. The San Raffaele ALS Centre is part of the Institute of Experimental Neurology (INSPE), which is primarily dedicated to translational research in the neuroscience field, conjugating high level of basic research with the specific competences in pre-clinical and clinical research. Activities span to clinical research (e.g clinical trials MRI, wet biomarkers) to basic research activities (e.g.: novel drug development, animal and cellular models, human iPSCs), in collaboration with several laboratories in Italy and Europe.
| The San Raffaele ALS Centre | |
|---|---|
| Principal investigator | Prof. Massimo Filippi, MD, FEAN, FAAN |
| Contact information | |
|---|---|
| Address | IRCCS Ospedale San Raffaele |
| Contact | Prof. Massimo Filippi, Prof. Federica Agosta |
| Phone | +39-2-26433954 and 3063 |
| Fax | +39-2-26433085 |
| filippi.massimo@hsr.it and agosta.federica@hsr.it | |
| Website | Visit the website |
Publications
Spinelli EG, Ghirelli A, Basaia S, Canu E, Castelnovo V, Cividini C, Russo T, Schito P, Falzone YM, Riva N, Filippi M, Agosta F. Structural and Functional Brain Network Connectivity at Different King’s Stages in Patients With Amyotrophic Lateral Sclerosis. Neurology. 2024 Jan 23;102(2):e207946. doi: 10.1212/WNL.0000000000207946.
Domi T, Schito P, Sferruzza G, Russo T, Pozzi L, Agosta F, Carrera P, Riva N, Filippi M, Quattrini A, Falzone YM. Unveiling the SOD1-mediated ALS phenotype: insights from a comprehensive meta-analysis. J Neurol. 2024 Mar;271(3):1342-1354. doi: 10.1007/s00415-023-12074-6.
Schito P, Russo T, Domi T, Mandelli A, Pozzi L, Del Carro U, Carrera P, Agosta F, Quattrini A, Furlan R, Filippi M, Riva N. Clinical Features and Biomarkers to Differentiate Primary and Amyotrophic Lateral Sclerosis in Patients With an Upper Motor Neuron Syndrome. Neurology. 2023 Aug 22;101(8):352-356.
Canu E, Castelnovo V, Rancoita PM, Leocadi M, Lamanuzzi A, Spinelli EG, Basaia S, Riva N, Poletti B, Solca F, Verde F, Ticozzi N, Silani V, Abrahams S, Filippi M, Agosta F. Italian reference values and brain correlates of verbal fluency index – vs standard verbal fluency test – to assess executive dysfunction in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2023 Aug;24(5-6):457-465. doi: 10.1080/21678421.2023.2167606.
Falzone YM, Domi T, Mandelli A, Pozzi L, Schito P, Russo T, Barbieri A, Fazio R, Volontè MA, Magnani G, Del Carro U, Carrera P, Malaspina A, Agosta F, Quattrini A, Furlan R, Filippi M, Riva N. Integrated evaluation of a panel of neurochemical biomarkers to optimize diagnosis and prognosis in amyotrophic lateral sclerosis. Eur J Neurol. 2022 Jul;29(7):1930-1939. doi: 10.1111/ene.15321.
Restricted information
| Serving population | |
|---|---|
| Serving population | 100.000 to 1.000.000 |
| Patient resources | |
|---|---|
| Population based register | No |
| Clinic based register | Yes |
| Geographically matched controls | Yes |
Banks
| Type | ALS Patients | Controls | Other |
|---|---|---|---|
| Biobank (DNA, serum, plasma, CSF, fibroblasts) |
| Research activities | |
|---|---|
| Clinical management research | Yes |
| Neuro epidemiology | Yes |
| Neuro physiology | Yes |
| Neuro imaging | Yes |
| Neuro psychology | Yes |
| Neuro pathology | Yes |
| Genomics | Yes |
| Transcriptomics | Yes |
| Metabolomics | No |
Clinical Trials - Industry sponsored
There are no clinical trials for this centre
Clinical Trials - Investigator initiated
There are no clinical trials for this centre