San Camillo Forlanini Hospital, Center for Neuromuscular and Neurological Rare Diseases

Foundation year1980
DirectorDr Antonio Petrucci
Principal investigatorDr Antonio Petrucci

The Center is principally devoted to diagnosis and management of patients with Amyotrophic Lateral Sclerosis; it is located at San Camillo Forlanini Hospital, one of the major hospitals of the city, it offers a multidisciplinary approach to the disease, including the genetic studies. Regarding scientific research, our primary interests lie in the neurophysiological aspects of the disease, in the biomarker investigation and in the possible  muscle involvement in determining the disease,  In these studies we collaborate closely with La Sapienza University and Tor Vergata University of Rome, Italy.

Contact Information

AddressCenter for Neuromuscular and Neurological Rare DiseasesC.ne Gianicolense 8700152 Italy

Emailanpetrucci@scamilloforlanini.rm.it

Center data

Serving population
Approximately 50 patients per year
Population based register
Clinic based register
Geographically matched controls
Number of skin samples
28
Number of spinal cord samples
0
Number of brain samples
0
Number of IPS cell samples
0

Banks

TypeALS PatientsControlsOther
DNA bank
74
-
-
Serum bank
124
-
-
RNA bank
0
-
-

Research Activities

Clinical management research
Neuro epidemiology
Neuro physiology
Neuro imaging
Neuro psychology
Neuro pathology
Genomics
Transcriptomics
Metabolomics

Publication

  1. Mutated sigma-1R disrupts cell homeostasis in dHMN patient cells.
    Sofia Zanin , Francesco Ciscato , Antonio Petrucci , Annalisa Botta , Federico Chiossi, Giovanni Vazza, Rosario Rizzuto , Giorgia Pallafacchina
    Cell Mol Life Sci. 2025 Apr 9;82(1):151. doi: 10.1007/s00018-025-05676-y
  2. Retrospective observational study on the use of acetyl-L-carnitine in ALS.Sassi S, Bianchi E, Diamanti L, Tornabene D, Sette E, Medici D, Matà S, Leccese D, Sperti M, Martinelli I, Ghezzi A, Mandrioli J, Iuzzolino VV, Dubbioso R, Trojsi F, Passaniti C, D’Alvano G, Filosto M, Padovani A, Mazzini L, De Marchi F, Zinno L, Nuredini A, Bongioanni P, Dolciotti C, Canali E, Toschi G, Petrucci A, Perna A, Riso V, Inghilleri M, Libonati L, Cambieri C, Pupillo E.J Neurol. 2023 Jun 28. doi: 10.1007/s00415-023-11844-6.
  3. Prevalence of amyotrophic lateral sclerosis in Latium region, Italy.Puopolo M, Bacigalupo I, Piscopo P, Lacorte E, Di Pucchio A, Santarelli M, Inghilleri M, Petrucci A, Sabatelli M; Latium Registry Group, Vanacore N.Brain Behav. 2021 Oct 30:e2378. doi: 10.1002/brb3.2378. Online ahead of print. PMID: 34716673
  4. A longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients.Dobrowolny G, Martone J, Lepore E, Casola I, Petrucci A, Inghilleri M, Morlando M, Colantoni A, Scicchitano BM, Calvo A, Bisogni G, Chiò A, Sabatelli M, Bozzoni I, Musarò A.Cell Death Discov. 2021 Jan 11;7(1):4. doi: 10.1038/s41420-020-00397-6
  5. Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signaling.
    Gregianin E, Pallafacchina G, Zanin S, Crippa V, Rusmini P, Poletti A, Fang M, Li Z, Diano L, Petrucci A, Lispi L, Cavallaro T, Fabrizi GM, Muglia M, Boaretto F, Vettori A, Rizzuto R, Mostacciuolo ML, Vazza G.
    Hum Mol Genet. 2016; Sep 1;25(17):3741-3753.