Tricals

    IRCCS Foundation “Carlo Besta” Neurological Institute

    Foundation year2020
    DirectorGiuseppe Lauria
    Principal investigatorRiva Nilo

    The IRCCS Foundation “Carlo Besta” Neurological Institute, is a center of excellence for research and treatment of the most important neurological diseases. It synergistically combines the activities of scientific research, diagnosis and treatment – which gives rise to a continuous improvement of therapeutic efficacy – in the field of clinical and basic neurology and deals with neurological disorders in adults and children, neurosurgical and oncological pathologies, chronic and rare diseases.

    Contact Information

    AddressMilanoVia Celoria, 1120133 Italy

    ContactIRCCS Foundation “Carlo Besta” Neurological Institute

    Phone390223942304
    Emailnilo.riva@istituto-besta.it

    Restricted information

    Serving population
    400.000

    Patient resources

    Population based register
    Clinic based register
    Geographically matched controls
    Number of skin samples
    100
    Number of spinal cord samples
    3
    Number of brain samples
    3
    Number of IPS cell samples
    50

    Banks

    Research activities

    Clinical management research
    Neuro epidemiology
    Neuro physiology
    Neuro imaging
    Neuro psychology
    Neuro pathology
    Genomics
    Transcriptomics
    Metabolomics

    Publication

    1. Update on recent advances in amyotrophic lateral sclerosis. Riva N, Domi T, Pozzi L, Lunetta C, Schito P, Spinelli EG, Cabras S, Matteoni E, Consonni M, Bella ED, Agosta F, Filippi M, Calvo A, Quattrini A. J Neurol. 2024 Jul;271(7):4693-4723. doi: 10.1007/s00415-024-12435-9. Epub 2024 May 27. PMID: 38802624
    2. MiR-146a in ALS: Contribution to Early Peripheral Nerve Degeneration and Relevance as Disease Biomarker. Giagnorio E, Malacarne C, Cavalcante P, Scandiffio L, Cattaneo M, Pensato V, Gellera C, Riva N, Quattrini A, Dalla Bella E, Lauria G, Mantegazza R, Bonanno S, Marcuzzo S.
    3. Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis. Riva N, Gentile F, Cerri F, Gallia F, Podini P, Dina G, Falzone YM, Fazio R, Lunetta C, Calvo A, Logroscino G, Lauria G, Corbo M, Iannaccone S, Chiò A, Lazzerini A, Nobile-Orazio E, Filippi M, Quattrini A. Brain. 2022 Mar 29;145(1):276-284. doi: 10.1093/brain/awab285. PMID: 35076694
    4. The unfolded protein response in amyotrophic later sclerosis: results of a phase 2 trial. Dalla Bella E, Bersano E, Antonini G, Borghero G, Capasso M, Caponnetto C, Chiò A, Corbo M, Filosto M, Giannini F, Spataro R, Lunetta C, Mandrioli J, Messina S, Monsurrò MR, Mora G, Riva N, Rizzi R, Siciliano G, Silani V, Simone I, Sorarù G, Tugnoli V, Verriello L, Volanti P, Furlan R, Nolan JM, Abgueguen E, Tramacere I, Lauria G. Brain. 2021 Oct 22;144(9):2635-2647. doi: 10.1093/brain/awab167. PMID: 33905493