The Department of Neurology of the Medical University of Warwaw is a Polish referential center for diagnosis and treatment of neuromuscular diseases. It diagnoses between 50 and 80 new ALS patients yearly.
The Neurodegenerative Diseases Research Group concentrates on the role of motor proteins in pathogenesis of ALS, identification of disease-related gene mutations, electrophysiological and neuroimaging characterization of ALS patients with various clinical phenotypes, protein profiling and deep phenotyping. The group collaborates with several partners from Europe, Japan and US. In the beginning of 2014, a JPND-founded scientific project „Needs in ALS“ concerning factors determining end-of life decisions in patients with ALS was started together with the Medical University of Ulm, Germany, and University of Umea, Sweden.
In 2003, in cooperation with the Department of Neurology in Ulm (Germany), a Warsaw ALS biobank was settled at the Department of Neurology and Department of Biochemistry, Medical University of Warsaw. The bank contains over 500 samples of EBV-immortalized lymphocytes obtained from patients with ALS and mimicking disorders.
| Department of Neurology, Medical University of Warsaw | |
|---|---|
| Foundation year | 2003 |
| Director | Prof. Anna Kaminska |
| Principal investigator | Assoc. Prof. Magdalena Kuzma-Kozakiewicz |
| Contact information | |
|---|---|
| Address | Banacha 1 |
| Phone | +48 22 5992857 |
| Fax | +48 22 5991857 |
| neurologia1-sekretariat@wum.edu.pl | |
| Website | Visit the website |
Publications
- Lehnert S, Costa J, de Carvalho M, Kirby J, Kuzma-Kozakiewicz M, Morelli C, Robberecht W, Shaw P, Silani V, Steinacker P, Tumani H, Van Damme P, Ludolph A, Otto M. Multicentre quality control evaluation of different biomarker candidates for amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Feb 28. [Epub ahead of print]
- Gawel M, Kuzma-Kozakiewicz M, Szmidt-Salkowska E, Kaminska A. Are we really closer to improving the diagnostic sensitivity in ALS patients with Awaji criteria? Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):257-61.
- Kuzma-Kozakiewicz M, Chudy A, Kazmierczak B, Dziewulska D, Usarek E, Baranczyk-Kuzma A. Dynactin Deficiency in the CNS of Humans with Sporadic ALS and Mice with Genetically Determined Motor Neuron Degeneration. Neurochem Res. 2013 Sep 28. [Epub ahead of print]
- Kuzma-Kozakiewicz M, Berdynski M, Morita M, Takahashi Y, Kawata A, Kaida K, Ka?mierczak B, Lusakowska A, Goto J, Tsuji S, Zekanowski C, Kwieci?ski H. Recurrent K3E mutation in Cu/Zn superoxide dismutase gene associated with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Dec;14(7-8):608-14.
- Jamrozik Z, Lugowska A, Golebiowski M, Królicki L, Maczewska J, Kuzma-Kozakiewicz M. Late onset GM2 gangliosidosis mimicking spinal muscular atrophy. Gene. 2013 Sep 25;527(2):679-82.
Restricted information
| Serving population | |
|---|---|
| Serving population | Unknown |
| Patient resources | |
|---|---|
| Population based register | No |
| Clinic based register | No |
| Geographically matched controls | No |
Banks
There are no banks for this centre
| Research activities | |
|---|---|
| Clinical management research | No |
| Neuro epidemiology | No |
| Neuro physiology | No |
| Neuro imaging | No |
| Neuro psychology | No |
| Neuro pathology | No |
| Genomics | No |
| Transcriptomics | No |
| Metabolomics | No |
Clinical Trials - Industry sponsored
There are no clinical trials for this centre
Clinical Trials - Investigator initiated
There are no clinical trials for this centre