Tricals

    ALS Unit, Neurology Department, Hospital Universitari i Politècnic La Fe

    Foundation year2014
    DirectorTeresa Sevilla
    Principal investigatorJuan F Vázquez-Costa

    Our ALS Unit attends 150 patients/year, being the reference Unit for ALS in the Valencian region (5.000.000 inhabitants). Our ALS research group is part of the research group on neuromuscular diseases and ataxias and is integrated in the spanish rare diseases network (CIBERER). Our main research interests are the genetic characterization of our patient cohort and the search of neuroimaging biomarkers.

    Contact Information

    AddressValenciaAvda Fernando Abril Martorell 106-Torre D, 546026 Spain

    Phone34961245542
    Emailvazquez_juacos@gva.es

    Restricted information

    Serving population
    100.000 to 1.000.000

    Patient resources

    Population based register
    Clinic based register
    Geographically matched controles
    Number of muscle samples
    20
    Number of skin samples
    0
    Number of spinal cord samples
    0
    Number of brain samples
    0
    Number of IPS cell samples
    0

    Banks

    TypeALS PatientsControlsOther
    DNA Bank
    220
    0
    8
    CSF Bank
    60
    0
    0
    Serum Bank
    220
    0
    8

    Research activities

    Clinical management research
    Neuro epidemiology
    Neuro physiology
    Neuro imaging
    Neuro psychology
    Neuro pathology
    Genomics
    Transcriptomics
    Metabolomics

    Publication

    Publications can be viewed via the profile of Juan Vázquez-Costa.

    • Vázquez-Costa JF, Alabajos A, Guevara M, Roda C, Sevilla T. Safety and efficacy of botulinum toxin A for the treatment of spasticity in amyotrophic lateral sclerosis: results of a pilot study. J Neurol. 2016;263(10):1954-60.
    • Vázquez-Costa JF, Bataller L, Vílchez JJ. Primary lateral sclerosis and hereditary spastic paraplegia in sporadic patients. Ann Neurol. 2016:24671. doi:10.1002/ana.24671.
    • Arlandis S, Vázquez-Costa JF, Martínez-Cuenca E, Sevilla T, Boronat F, Broseta E. Urodynamic findings in amyotrophic lateral sclerosis patients with lower urinary tract symptoms: Results from a pilot study. Neurourol Urodyn. 2016. doi:10.1002/nau.22976.
    • Vázquez-Costa JF, Beltrán E, Sopena P, et al. Clinical and neuroimaging characterization of two C9orf72-positive siblings with amyotrophic lateral sclerosis and schizophrenia. Amyotroph Lateral Scler Frontotemporal Degener. 2015:1–4. doi:10.3109/21678421.2015.1112407.
    • Dols-Icardo O, Nebot I, Gorostidi A, et al. Analysis of the CHCHD10 gene in patients with frontotemporal dementia and amyotrophic lateral sclerosis from Spain. Brain. 2015:awv175. doi:10.1093/brain/awv175.